The hipouricemia effects of ethanol extract with doses of 80 and 160 mg/kg BW are 91.95% and 91.77% compared to those of allopurinol with doses of 20 and 40 mg/kgBW, respectively. Based on the in vivo study, it could be concluded that the ethanol extract of Tunjuk langit has hipouricemia potency. The uric acid level and the percentage of its degradation of each group were measured on the 20 th, 25 th and 30 th days. Meanwhile, chicken liver juice was also still given constantly within these days. Extract tests were orally injected to the groups with each dose starting from the 15 th day until 30 th day. The blood uric acid levels were measured on the 10 th and 15 th days. The uric acid level of their blood was measured on the day-0 and these groups were then inducted with a mixture of chicken liver juice (25 ml/kg BW 2 times/days) and Gnetum gnemon seeds (2g/kg BW per day) from day-0 until day-30. Group I: normal group (CMC-Na 0.5% with dose of 10 mL/kg BB), Group II : negative control, Group III-VI : positive control (alopurinol with doses of 5, 10, 20 and 40 mg/kg BB) and VII-X : Ethanol extract with doses of 20, 40, 80, and 160 mg/kg BB. In this study, 50 mice were divided into 10 groups (n=5 per group). The main purpose of this research is to understand the hipouricemia potency of ethanol extract of tunjuk langit compared to that of alopurinol. Other studies revealed that the rhizome of tunjuk langit has antioxidant, anticancer, neuroprotective and anti-inflammatory effects. Tunjuk langit (Helminthostachys zeylanica) rhizome has been used as traditional medicines.
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